The church's 44-rank pipe organ draws excellent organists who perform in recital. In 2015, world-renowned organist, Paul Jacobs, performed a concert at Holy Cross, sponsored by the Tryon Concert Association. Organists Robert J. Powell, Brennan Szafron, Charles Tompkins, and Thomas Strauss have also performed recitals at Holy Cross in recent years.

Area musicians perform on the Bach's Lunch Wednesdays at Noon Lenten Recital Series each year. Parishioners and members of the community attend these 30 minute recitals, performed by area musicians.

Other groups performing concerts at Holy Cross have been Asheville's a cappella vocal group, Pastyme; the Blue Ridge Ringers, a community handbell ensemble based in westernNorth Carolina; and Vocal Impressions, Polk County High School's premier vocal ensemble.